I use a RJM Mastermind to control the whole rig, which is why I am posting here. I run a hybrid rig. My heavy/distorted tone is as close to pure as I can get with the signal path being only wireless/wah/5150/cab. For my clean tones I run the POD to the 5150 poweramp. For my fun leads I run them in parallel to each other. The ability to run both together adds a whole other level to programming/annoyance.