Strymon Mobius OFF

If you have a button that turns the pedal on and off, and that button has Send on Preset Change turned on, it's probably sending a bypass message to the pedal on every preset change.

If I guessed correctly, just program that button to turn on in the presets where you want the pedal to be on. It will send the "on" message on those presets and the "off" message on the presets where you want it off.

If that's not it, I'm going to need to look at your settings file to see what's going on.